Is NMN Really Effective? NMN’s efficacy has evolved amid over a century of research and debate; its path has been far from smooth, and it was nearly halted early on. As early as 120 years ago, British scientists first discovered NAD⁺ and gradually confirmed that this coenzyme is central to energy metabolism in animal and human cells. Researchers began to recognize its relevance to muscle function, neural activity, and aging at the cellular level. Then, in 2013, a landmark stu